Using Homm 5 gold edition (Homm 5 + Hammer of fate + Tribes of east).
The first DVD (of 3 in the package) contains both the original Homm5 and the Hammers of fate expansion (the first in a dir name H5 and the second in a dir named H5A).

1. Mount the DVD (in my Mandriva 2010.1 x86_64 in "/media/cdrom").

2. Run the script

3. In the Playonlinux wizard cdrom screen, enter "/path/to/mounted/cd" (in my case: /media/cdrom)

4. Watch the error: "Unable to find the CDROM!"

The above error could be caused by the script searching for "Setup.exe" in the DVD root dir: but here there are only the dirs and files below:
******************
Autorun (dir)
H5 (dir) ==> contains setup.exe for Homm5 original
H5A (dir) ===> contains setup.exe for Hammer of fate expansion
Support (dir)
unicows.dll
AutoRun.exe
AutoRun.ico
autorun.inf
******************