Not yet. They are apparently working on a way to get it to run, but it takes time. They will have to come up with a new version that runs on 64 bit Macs. Another problem is that Wine doesn't work on Catalina, so they have a lot of work to do to get it to run. I am in the same boat as you, waiting for them to get it to work. I just got a new computer with Catalina. I am sure they will let us know when PlayOnMac is compatible with Catalina on the other thread. Just follow the other thread, and you will know soon enough.