I have installed Diablo 3 on my new Ubuntu12.10 computer with Wine 1.5.5 using playonlinux. I am finding that it will crash between 30-60 minutes of gameplay. Then if I keep playing it will move down to about 5 minutes after startup. I am running an intel i5 3570k with a gtx 660 graphics card. I have tried installing vcrun2008 and it seems not to help. In fact, it might have made it worse. When running, the game looks great, and I can run everything on high without problems.