Running Linux Mint 17 here, finally got everything running more or less. Only when I fire up DiabloIII.exe POL error - stating nothing but that it encountered an error. :) And then battle.net fires up, and everything runs as expected. I just had to use "echo 0 | sudo tee /proc/sys/kernel/yama/ptrace_scope" to get past the connection issues - and I'm game. Now I just need to fix my horrid fps.
From what I've read online, -setarch has become obsolete, but it used to fix some of the issues you're encountering.
Running POL 4.2.2 + Wine version 1.7.19