I'm able to play Gothic 2 on my system thanks to the Gothic 2 script included.
Wine version: 1.3.26
Distribution version: 10.04 (Lucid) heavily updated
Graphics card: ATI RV730XT [Radeon HD 4670]
Graphics card driver: AMD Catalyst 11.6 for Linux
Comments: Script not working, but Game itself works (see #223)
Installation was done "manually" with several components. I looked up http://www.playonmac.com/repository/?script=465 to find out all the dependencies to be installed.
I did rip a part of the scripts and updated it to my gothic variant to have all registry etc. setting correct (mainly the DX3D and DM DLL).
Playing in windows mode makes it easier to change to the browser/editor etc.
ToDo: Finetuning of the gamepad settings, the dead zone is too small (i.e. extremely sensitive)